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|Drinking coffee may reduce all-cause mortality||11/28/18|
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|All Health and Nutrition Bites|
Omega-3 Fatty Acids May Prevent Cellular Aging
Your cells are constantly dying and being replaced by new cells, which are created by cell division. Telomeres are DNA sequences, and multiples of these telomeres form a protective cap on the ends of certain chromosomes. As these chromosomes are divided to create new cells, one or more of these telomeres are stripped from the ends of the chromosomes, which eventually leads to the breakdown of the chromosome and cellular death.
Coffee Reduces Inflammation Markers
There have been conflicting studies about the effects of coffee-drinking on overall markers of inflammation as well as the function of the endothelium (the lining of the arteries). The theory is that inflammation can cause a lack of proper responsiveness of the artery as far as relaxation, as well as impairing its ability to respond to injury and inflammation.
Inflammation is the body's response to things that might cause damage: this might include dysfunctional cells, invading foreign agents (like a virus or a bacteria) or exposure to toxins. The purpose of inflammation is to attract immune cells to destroy the damaging invader and return the tissue to normal. Acute inflammation is a temporary response, with the probably familiar signs of heat, redness, swelling, pain, and perhaps loss of function.
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Today's research article notes that there is a long-standing association of obesity with chronic pain. That might seem obvious to you - obesity puts a lot of stress on the body, including greater back pain and pain in the joints from the strain of moving and bearing excess weight. But are there other ways that obesity contributes to pain? We know that excess fat contributes to increased inflammation, and inflammation contributes to pain. If so, then might foods that we know are anti-inflammatory have some effect on that pain?
A team at Ohio State University designed a study to assess the relationship between obesity and pain and whether diet might have some influence on pain levels. They recruited 49 otherwise healthy but clinically normal weight men and women and 49 clinically obese men and women, all between the ages of 20 and 78, to participate in their study, taking care to match the participants in the two groups as closely as they could with regard to sex, age, race/ethnicity, and level of education (Pain 2017;158:273-77).
The participants were visited at home by trained interviewers, who administered a standardized dietary questionnaire designed to assess the participant's adherence to the Healthy Eating Index 2010 (HEI-2010), which corresponds to the 2010 Dietary Guidelines for Americans. They also measured height, weight, and waist circumference, and used a bioimpedence analyzer to measure body fat. Further, they administered standard clinical surveys designed to assess physical pain as well as anxiety or depression.
Initially the authors simply looked at the association between the participants' Body Mass Index and their reported levels of pain, which showed that yes, higher levels of BMI were associated with higher levels of pain. But when they added in the participants' overall HEI-2010 score as a mediator, the association was no longer significant.
The researchers controlled for diagnoses of arthritis or reports of joint pain, took into account whether the participants were taking pain medication, and finally tried using waist circumference and body fat instead of BMI, but it was still clear that the HEI-2010 score had a significant effect on pain. Finally they broke out the 12 components of the HEI-2010 to discover that only a higher intake of seafood and plant proteins was responsible for the dietary effect on pain.
This is a cross-sectional study based on the participants remembering what they ate in the last 24 hours, which is subject to the vagaries of human memory as well as the possible desire to be seen to eat more healthfully than one does. That said, this does suggest that a healthier, anti-inflammatory diet like the Mediterranean Diet, with its emphasis on higher intake of seafood and legumes, including beans, lentils, and soybeans, can help counteract the pain associated with obesity.
First posted: March 1, 2017